Differential Psoriatic Effect of Imiquimod on Balb/c and Swiss Mice

Abstract Introduction The influence of animal strain on psoriasis model development by imiquimod (IMQ) has been studied in Balb/c and Swiss mice. Materials Methods Female mice either were challenged with 5% IMQ (62.5 mg back skin, 10 right ear). They observed for the severity disease using Psoriasis area index (PASI), splenomegaly, histopathological alterations. To validate model, well-established antipsoriatic drug clobetasol (0.05%, 120 ear) was used. Additionally, to study strain-dependent response associated oxidative stress, various antioxidant factors like superoxide dismutase (SOD), catalase (CT), glutathione (GSH) measured. Antioxidant natural product curcumin (1%, 150 12.5 used evaluate alleviation stress distinct strain. Results PASI score, body weight, histopathology indicated both strains, severity, stability which dependent particular Splenomegaly suggested systemic effect, comparable stains. its involvement redox status confirmed an alteration activity SOD, CT, levels GSH. Conclusion This demonstrated that, IMQ-induced genetic background some impact stability, imbalance.